IMBT System
Pro-MI
Proton Therapy01 / 07
Narrow minibeams reduce normal tissue dose along the beam path
Depth-dose modulator ensures uniform dose at the tumor site
Dose-volume effect + repair effect protect OARs surrounding the tumor
Six-component system: MSC, depth-dose modulator, range shifter, scatterers, holder, neutron absorber
Mounts directly onto existing proton therapy equipment nozzles
Three-layer protection: beam path / surrounding OARs / tumor control
Proton Minibeam Radiation Therapy (pMBRT) that reduces dose to normal tissues along the beam path while maintaining tumor control — spatially fractionated narrow beams deliver uniform dose at depth.
Pro-MI (PROton MInibeam radiation therapy) is a proton minibeam radiation therapy technology that reduces dose to normal tissues along the beam path while maintaining tumor treatment efficacy using spatially fractionated narrow proton beams. A multislit collimator (MSC) divides the scanned pencil beam into multiple minibeams, creating a high Peak-to-Valley Dose Ratio (PVDR) at the skin surface, while a depth-dose modulator ensures uniform dose distribution at the deep tumor site.
The dose-volume effect and repair effect of narrow beams work in combination to protect normal tissues along the beam path and organs at risk (OARs) surrounding the tumor. Unnecessary dose along the beam path — a known limitation of conventional proton therapy — is substantially reduced while tumor control is maintained.
The pMBRT system consists of six components: a multislit collimator (brass), depth-dose modulator, range shifter (polymer), scatterers (lead or bismuth), system holder, and neutron absorber (PE with boron). The system is designed to mount directly onto the nozzle of existing proton therapy equipment.
- Proton minibeam therapy workflow that reduces normal tissue exposure along the beam path while preserving tumor treatment efficacy
- Integrated minibeam delivery system mountable directly onto existing proton therapy equipment nozzles
- Minimizing beam-path and surrounding OAR dose for tumors adjacent to radiation-sensitive structures
- Leveraging dose-volume effect and repair effect of spatially fractionated beams for normal tissue recovery
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